Application of CMC Cellulose Gum in Medicine

CMC cellulose gum can be used as emulsion stabilizer of injection, binder of tablet and film-forming agent in pharmaceutical industry. It has been proved by basic and animal experiments that CMC is a safe and reliable carrier of anticancer drugs. The modified formulation of nourishing yin and promoting granulation, nourishing yin and promoting granulation membrane, which uses CMC cellulose gum as membrane material, can be used for surgical wound of skin grinding and traumatic wounds. The results of animal model study showed that the membrane could prevent wound infection and had no significant difference with gauze dressing. This membrane is superior to gauze dressing in controlling exudation of wound tissue and rapid healing of wound. It can also reduce postoperative edema and wound irritation. The best prescription of preparation of membrane agent: Polyvinyl alcohol: cmc cellulose gum: polycarboxyethylene in the proportion of 3:6:1. Adhesion and release rate is increased. It can increase the adhesion of the sustained-release film, prolong the retention time in the oral cavity and improve the efficacy of the drug. Bupivacaine is a powerful local anesthetic, so it can produce serious cardiovascular side effects when poisoned. Therefore, when bupivacaine is widely used in clinic, more attention has been paid to the prevention and treatment of its toxicity.

According to the study of the medicament, as a slow-release material and bupivacaine solution, CIVIC can significantly reduce the side effects of the drug. In PRK operation, low concentration of dicaine combined non-steroid anti-inflammatory drug and cmc cellulose gum can significantly relieve postoperative pain. One of the most concerned problems in clinical surgery is to prevent peritoneal adhesion and reduce the incidence of intestinal obstruction after abdominal operation. Some studies have shown that cmc cellulose gum is superior to sodium hyaluronate in reducing the degree of postoperative peritoneal adhesion. It can be used as an effective method to prevent peritoneal adhesion. CMC cellulose gum is used in intrahepatic arterial infusion of anticancer drugs for liver cancer, which can obviously prolong the retention time of anticancer drugs in tumor, enhance the anti-tumor ability and improve the therapeutic effect.